Drug reduces enlarged prostate with few side effects



































Relief from the constant call of nature is the aim of a new drug, tested in rats, which can shrink an enlarged prostate and is likely to have few side effects.











By the age of 60 an estimated 70 per cent of men have prostate enlargement. Treatment involves surgery or drugs that block testosterone, a hormone that drives unwanted growth. Side effects can include loss of libido and erectile dysfunction.













The new drug, RC-3940-II, developed by Andrew Schally of the Miami Veterans Affairs Medical Center in Florida and colleagues works by blocking gastrin-releasing peptide – another potent growth factor.












In rats, a six-week treatment shrank prostates by 18 per cent. It also shrank human prostate cells by 21 per cent. Importantly, fewer side effects are likely as testosterone pathways are avoided.












Journal reference: PNAS, DOI: 10.1073/pnas.1222355110




















































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Israeli vote doesn't nail shut door to peace: Clinton






WASHINGTON: The outcome of Israel's elections did not torpedo hopes for peace with the Palestinians, but instead opened up a new chance for dialogue, US Secretary of State Hillary Clinton argued Tuesday.

"I actually think this election opens doors, not nails them shut," she said, during a so-called "global townhall" meeting, in which she took questions from Internet-users and broadcasters around the world.

Israeli Prime Minister Benjamin Netanyahu's Likud-Beitenu list emerged from last week's vote with the biggest single share of seats in the Knesset, but was weakened by a surge in support for Yair Lapid's centrist Yesh Atid party.

Party leaders are negotiating a new coalition, which is expected to have a centre-right bent, and the talks are being watched for signs as to whether it will be able to revive the Middle East peace process.

According to Israeli reports, Netanyahu has offered Lapid the post of foreign minister or finance minister in a new government. And while Lapid has rarely spoken about foreign policy challenges or the Israeli-Palestinian peace process, he has said he favours negotiations.

Clinton, in one of her final public engagements before she steps down from US President Barack Obama's administration, chose to strike an optimistic note.

She said: "A significant percentage of the Israeli electorate chose to express themselves by saying, 'We need a different path than the one we have been pursuing internally and with respect to the Middle East peace process.'

"So I know President Obama and my successor soon-to-be secretary of state John Kerry will pursue this, will look for every possible opening."

As Clinton was speaking, the US Senate Foreign Relations Committee gave its backing to Kerry's appointment, clearing the way for the full Senate to confirm him as her successor later in the day.

Last week, in his confirmation hearings, Kerry appeared to hint he may have new proposals up his sleeve to restart direct peace talks between Israel and the Palestinians which have stalled for more than two years.

"We need to try to find a way forward, and I happen to believe that there is a way forward," he said.

"But I also believe that if we can't be successful that the door, or window, or whatever you want to call it, to the possibility of a two-state solution could shut on everybody and that would be disastrous in my judgment."

Both Israel and the Palestinian Authority have theoretically committed themselves to the goal of a "two-state solution" with both living side-by-side within agreed borders.

But direct talks have foundered, with Palestinians decrying ongoing Israeli settlement building on occupied territory and Israel denouncing rocket attacks on its civilians from Gaza, which is controlled by the Hamas militia.

Clinton told the Washingon townhall meeting that she believed "Hamas is not interested in democracy... is still largely a military resistance group."

But she added: "We've made it very clear that if Hamas renounces violence, if they morph themselves into a political entity the way that Fatah and the Palestinian Authority have from the origins in the PLO, if they accept the previous commitments... there's a place for them at the table. And it would be my great hope that they would do that."

- AFP/jc



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Internet, social media least trusted industries for privacy



Internet and social media ranked bottom on a list of the most trusted industries for privacy, according to the Ponemon Institute.

Released yesterday, Ponemon's "2012 Most Trusted Companies for Privacy" was compiled from a survey of U.S. adults asked to name the five companies they trust the most to protect the privacy of their personal information.


Based on more than 6,700 responses, several tech players were absent from the top 20 after being on it in past years.


Apple failed to make the top 20 for the first time in four years. Google, Best Buy, Facebook, Yahoo, Dell, and AOL also were gone from the top 20 after scoring good or decent grades in the past.


Those results aren't surprising as many of those polled expressed concern about certain technologies. A full 59 percent of the respondents said they feel their privacy rights are diminished or undermined by social media, smart mobile devices, and geo-tracking tools.


Almost half of the people surveyed said they received one or more data breach notifications over the past two years. And 77 percent of those said such notifications hurt their trust in the organization reporting the breach.


A majority of those polled said they've shared personal information with an organization they didn't know or trust, with most admitting they did it for the convenience of online shopping. And only 35 percent feel they have control over their personal information, a percentage that has dropped steadily over the past seven years, the report said.


Identify theft was seen as the most significant threat to privacy, followed by government surveillance and data breaches.


And what do people expect from companies that use their personal information?


Security protection was named the most important feature. But a majority also said they don't want their data shared without their consent and they want the ability to be forgotten.



On a more positive note, Hewlett Packard took second place in the rankings, just behind American Express.


Amazon was third, followed by IBM in fourth. eBay grabbed ninth place, with Intuit rounding out the top ten.


Among other technology providers, Microsoft and Mozilla joined the list for the first time, ranked 17 and 20, respectively. Verizon, AT&T, and WebMD also numbered among the top 20.


Conducted in December, the survey received responses from 6,704 people.


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Space Pictures This Week: Martian Gas, Cloud Trails

Image courtesy SDO/NASA

The sun is more than meets the eye, and researchers should know. They've equipped telescopes on Earth and in space with instruments that view the sun in at least ten different wavelengths of light, some of which are represented in this collage compiled by NASA and released January 22. (See more pictures of the sun.)

By viewing the different wavelengths of light given off by the sun, researchers can monitor its surface and atmosphere, picking up on activity that can create space weather.

If directed towards Earth, that weather can disrupt satellite communications and electronics—and result in spectacular auroras. (Read an article on solar storms in National Geographic magazine.)

The surface of the sun contains material at about 10,000°F (5,700°C), which gives off yellow-green light. Atoms at 11 million°F (6.3 million°C) gives off ultraviolet light, which scientists use to observe solar flares in the sun's corona. There are even instruments that image wavelengths of light highlighting the sun's magnetic field lines.

Jane J. Lee

Published January 28, 2013

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Obama's Immigration Plan to Have More Direct Path













President Barack Obama is expected to lay out his principles for immigration reform in a speech in Las Vegas today that will include a potentially quicker path to citizenship than the bipartisan plan a group of senators unveiled earlier this week.


The president will offer some new details about the White House's immigration reform plan, which expands on a blueprint it released in 2011, a senior administration official told ABC News. But for now Obama will stop short of offering his own piece of legislation because of the progress made by the Senate "Gang of Eight."


See Also: Senate Wants Immigration Bill Passed in Months


The White House has sounded positive notes about the Senate group's plan thus far, but the specifics that Obama announces are expected to have some key differences that might cause concern for some Republican senators who have signed onto the senate deal.


Like the senators' plan, Obama's proposal calls for a pathway to citizenship for many of the 11 million undocumented immigrants living in the U.S. The senators' plan would grant "probationary legal status" immediately to eligible undocumented immigrants, but would not allow them to apply for permanent legal status, or a green card, until the border is deemed to be secure. Think of that as a trigger system.


On the other hand, administration officials told media outlets that they believe a path to citizenship needs to be more straightforward. They believe a trigger system, like the one in the senate plan, could lead to a state of legal limbo for the undocumented immigrants who receive legal status, The Washington Post reported.








'Lucha Libre' Wrestler: Crusader Against Illegal Immigration Watch Video









The border-security-first plan, however, is essential to Republican senators who signed onto the Senate "Gang of Eight" deal.


"I will not be supporting any law that does not ensure that the enforcement things happen," Sen. Marco Rubio (R-Fla.), a member of the group, told conservative blogger Ed Morrissey on his web radio show.


See Also: 3 Flashpoints in the Senate Immigration Blueprint


Obama's plan is likely to include language that would allow same-sex bi-national couples to have the same rights as heterosexual couples, BuzzFeed and The Washington Post reported. Under current law, gays and lesbians who are married to U.S. citizens under state laws cannot obtain a green card. Obama's plan would allow them a path to citizenship, but the issue is not mentioned in the Senate "Gang of Eight" proposal.


As noted by the Post, that language may anger Christian groups who have signaled they would support comprehensive immigration reform.


But the White House remains optimistic about the progress that has been made so far. An official described the senators' announcement as a "breakthrough" to ABC News because it wasn't clear whether Republicans would sign on to any path to citizenship.


Some observers couched the Senate group's decision to come out with his plan a day before Obama as an attempt to outfox the White House politically. But administration officials told media outlets they remain generally pleased with the plan and believe that the president's speech could build momentum for a final bill.


Updated, 12:15 PM


The White House reiterated that the president was very encouraged by the Senate's proposal since it includes a pathway to citizenship that is endorsed by Republicans, who have previously opposed immigration reform that includes such a path.


"Our focus is that this is a positive development," White House spokesman Luis Miranda told ABC/Univision. "We feel very positive that there is a proposal in the first place and that it is consistent with what the president has supported in the past."


The White House clarified that it is withholding judgment on language in the Senate framework that requires a border security "trigger" to obtain a green card until actual legislative language is released by the senators.


"What we have said is that there needs to be a clear path to citizenship," said Miranda. "We'll wait to see what they flesh out."


ABC's Reena Ninan contributed reporting.



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Davos: Persuading big business to act on climate change



































There was good news and bad news from Davos this year. Dire warnings were issued about the dangers of climate change, but a new report argued that big businesses can limit the temperature rise – if only governments can unleash their potential.











Movers and shakers from business and government gathered in Davos, Switzerland, last week for the annual World Economic Forum (WEF). They discussed global risks like financial instability, rising food prices and climate change.













The new president of the World Bank, Jim Yong Kim, highlighted a recent report that predicted global temperatures could rise by 4 °C within decades. "My children could be living in a world that doesn't even resemble the one we live in now," he said.











Green money













It would take $700 billion of investment every year to cut greenhouse gas emissions to a safe level, while allowing continued economic growth.












That's according to the Green Investment Report, issued by the WEF during the meeting.












"We just don't have that much public money," says Dominic Waughray, a senior director of the WEF in Geneva, Switzerland, and one of the authors of the report. The 2008 financial crisis has slashed public funds, he says.












However, Waughray says governments can encourage the private sector to step up. Currently, the world's governments spend $96 billion a year tackling climate change. The WEF report estimates that if they increase that to $130 billion, governments could unleash $570 billion a year of private capital.












To do this, the public money must be used to encourage private investment in green technologies. Rather than funding projects like wind farms outright, Waughray wants the money used to reduce the risk for private investors.












Major infrastructure projects often receive this sort of support. If a company wants to build a power plant in a developing country, but is worried that the country could become unstable, it can buy a form of insurance from the World Bank's Multilateral Investment Guarantee Agency. If the host country becomes unstable and stops buying power from the plant, MIGA covers the lost income.












"The public money is the buffer so the private company feels comfortable with the project," says Waughray.











Stepping up













One such fund was launched in Davos. The International Finance Corporation, part of the World Bank, has started a Catalyst Fund to help companies that are tackling climate change by, for instance, building renewable power plants or boosting energy efficiency. It has already raised $280 million.











There are also signs that businesses are paying attention. In the run-up to the meeting, the Carbon Disclosure Project in London surveyed 2415 companies and found that 70 per cent believed climate change could significantly affect their revenues.













Their major concern is extreme weather events, which can disrupt supply chains. Nearly 700 of the companies were already investing in emissions cuts, and 63 per cent of those companies said they were doing so because climate change was a physical risk to their business.


















































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Iran sends monkey into space






TEHRAN: Iran on Monday successfully sent a monkey into orbit, paving the way for a manned space flight, Defence Minister Ahmad Vahidi told state television.

Arabic-language channel Al-Alam and other Iranian news agencies said the monkey returned alive after travelling in a capsule to an altitude of 120 kilometres (75 miles) for a sub-orbital flight.

"This success is the first step towards man conquering the space and it paves the way for other moves," General Vahidi said, but added that the process of putting a human into space would be a lengthy one.

"Today's successful launch follows previous successes we had in launching (space) probes with other living creatures (on board)," he added.

"The monkey which was sent in this launch landed safely and alive and this is a big step for our experts and scientists."

Iranian state television showed still pictures of the capsule and of a monkey being fitted with a vest and then placed in a device similar to a child's car-seat.

A previous attempt in 2011 by the Islamic republic to put a monkey into space failed. No official explanation was ever given.

A defence ministry statement quoted by Iranian media said earlier Iran had "successfully launched a capsule, codenamed Pishgam (Pioneer), containing a monkey and recovered the shipment on the ground intact".

Iran announced in mid-January its intention to launch a monkey into orbit as part of "preparations for sending a man into space," which is scheduled for 2020.

Iran's space programme deeply unsettles Western nations, which fear it could be used to develop ballistic missiles capable of carrying nuclear warheads they suspect are being developed in secret.

The same technology used in space launch rockets can also be used in ballistic missiles.

The Security Council has imposed on Iran an almost total embargo on nuclear and space technologies since 2007.

Tehran has repeatedly denied that its nuclear and scientific programmes mask military ambitions.

Iran's previous satellite launches were met by condemnation from the West who accused Tehran of "provocation."

The Islamic republic has previously sent a rat, turtles and worms into space. It has also successfully launched three satellites -- Omid in February 2009, Rassad in June 2011 and Navid in February 2012.

In mid-May last year, Tehran announced plans to launch an experimental observation satellite Fajr (Dawn) within a week but it did not happen and Iran gave no explanation for the delay.

The Fajr satellite was presented by Iranian officials as "an observation and measurement" satellite weighing 50 kilos (110 pounds), built by Sa-Iran, a company affiliated to the defence ministry.

- AFP/ir



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Newegg wins in key 'shopping cart' lawsuit



Newegg last week won an important ruling that could have a profound impact on e-commerce.


A U.S. Court of Appeals for the Federal Circuit last week ruled (PDF) that Newegg has not violated patents held by Soverain related to the function of shopping carts and other e-commerce technologies. The court found that Soverain's claims -- that Newegg was violating its patents through its online shopping cart -- were "invalid for obviousness."


Ars Technica was first to report on the judgement.


Soverain does not actually operate an e-commerce business. Instead, the company has acquired a wide array of patents across e-commerce that it has used to win judgement against several online retailers, including Victoria's Secret and Avon. In 2007, the company also won a verdict against Newegg on the claims that have now been overturned by the higher court.



What Soverain has been seeking (and receiving) from online retailers is nothing to scoff at. The company wins damages against the online retailers that it defeats, plus a "running" royalty of 1 percent of sales for the right to use its patents.


As Ars Technica points out, however, the Federal court's ruling could effectively alter Soverain's future. The company's patents, which in some cases, date all the way back to the 1990s, are now being called invalid because they're "obvious." It might not take long, therefore, for companies that it defeated in court to appeal judgements based on that ruling. The company has also brought lawsuits against a slew of other companies that are still pending and might be scuttled by this deal.


Here's what Newegg's chief legal officer, Lee Cheng, had to say to Ars Technica about Soverain:


Lo and behold, I unveil to you the world of--shopping cart! And this shopping cart--unlike all the shopping carts used for hundreds, if not thousands of years--should be paid for based on the total dollars of transactions in the shopping cart.

It's very common in troll cases for them to say, "Our widget is so critical, we deserve a penny on every dollar." But what they have is a completely commodity functionality that could be coded any one of dozens of different ways. I mean, come on. Let's not stretch credibility.


CNET has contacted Soverain for comment. We will update this story when we have more information.


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Doomed Dolphin Speaks to New York's Vibrant Wildlife


By the time New Yorkers spied a dolphin swimming through the superfund sludge of the Gowanus Canal last Friday, it was too late. The marine mammal didn't even survive long enough for a rescue plan to come together. First sighted on Friday afternoon, the dolphin perished at 6:00 p.m.

The reason the marine mammal died, and why the dolphin swam up the polluted waterway in the first place, is as yet unknown. But the sad story of the wayward creature highlights the strange nature of New York City, the global epitome of urbanity. Hidden within Gotham are native carnivores, marine mammals, and even species that have scarcely been seen before.

Marine mammals are arguably the most high-profile of New York City's wild residents and visitors. The Gowanus Canal dolphin was only the latest to venture within city limits. Just a month ago, a 60-foot-long finback whale (Balaenoptera physalus) became stranded in the Rockaway Inlet of Queens. The emaciated animal died the day after it was discovered.

There seems to be no singular reason explaining why marine mammals such as the Gowanus dolphin and Queens' finback whale wander up the city's rivers or strand on beaches. Each case is unique. But not all the city's marine mammal visitors suffer terrible fates.

In 2006, a hefty manatee (Trichechus spp.) took a long jaunt from its Florida home up the East Coast, including a detour down New York's Hudson River. The sirenian survived the trip, continuing on to Cape Cod before reportedly turning back south to a destination unknown. Hopefully the manatee didn't encounter any great white sharks (Carcharodon carcharias) on the return journey, a marine predator we know patrols the waters off New York.

Of course, New York City's whales, seals, and occasional manatee can only skirt the city along its shores and canals. You likely won't see a seal caterpillaring its way along Broadway.

Yet the city's interior also hosts a strange accumulation of wildlife, including native animals that are carving out spaces for themselves in the concrete corridors and exotic species that we have introduced to city life.

Coyotes (Canis latrans) may be the cleverest of New York City's hidden wildlife. Thanks to camera traps, and the occasional police chase through Lower Manhattan, researchers are keeping track of the wily canids and studying how they are so successfully taking up residence in many of the nation's cities. "Most small, urban parks will likely hold a pair and their offspring at most—coyotes are very territorial," said Cornell University ecologist Paul Curtis.

The secretive carnivorans bring a welcome element to urban neighborhoods—an appetite for rodents—and are experts at cracking open new niches alongside people.

Black bears (Ursus americanus) may be next. The bears have proliferated in northern New Jersey in recent years, and in 2010, a black bear came within three miles of the George Washington Bridge, a major thoroughfare between New Jersey and Manhattan. The bear obviously would have eschewed rush hour traffic and the tolls, but the local population is so bountiful that it's not unreasonable to think some enterprising bear might eventually wander into the big city.

Strangely, you may actually be more likely to run into a crocodylian predator in New York City than a black bear. New Yorkers have a nagging habit of importing—and losing-alligator—like caimans and other reptiles within the city.

In 2010, an 18-inch long caiman took refuge under a parked Datsun in Astoria, Queens. No one knows how the reptile wound up on the street, but given the trend of owners buying cute crocodylians and later dumping them, someone may have abandoned the poor little caiman.

This would hardly be the first time. In 2006, another little caiman was found in the leaf litter behind Brooklyn's Spring Creek Towers, while "Damon the Caiman" swam around a Central Park lake in the summer of 2001. These caimans are only some of the most famous—according to a New York Times report, the Brooklyn-based Animal Care and Control deals with about ten caimans each year.

Many other unusual and exotic animals have romped through New York. Under some of their most notable animal celebrities, the city's Parks and Recreation department lists guinea pigs, boa snakes, and even a tiger that escaped from a circus in 2004 and ran down Jackie Robinson Parkway before his owners were able to get him back.

The Big Apple even contains species that have never been documented before. No, not the ballyhooed "Montauk Monster"—actually a rotted raccoon—but a distinct species of leopard frog. Described early this year, the cryptic amphibian was given away by its unique mating call.


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Grand Jury Wanted to Indict JonBenet's Parents













A grand jury believed there was enough evidence in 1999 to indict John and Patsy Ramsey on charges relating to the still-unsolved killing of their beauty queen daughter JonBenet Ramsey, ABC News sources say.


Six-year-old JonBenet was found dead in the basement of her family's upscale Boulder, Colo., home Christmas Day 1996. Suspicion fell on her parents, John and Patsy Ramsey, but they insisted an intruder was to blame and they were never prosecuted.


In an interview with ABC News' Barbara Walters after her death, both of the girl's parents denied that they had killed her. They were eventually cleared by prosecutors.








JonBenet Ramsey Case: New Grand Jury Report Watch Video









After meeting for more than a year, a grand jury found sufficient evidence to indict the couple on charges of child abuse resulting in death, as first reported Sunday by the Boulder Daily Camera newspaper and confirmed by two separate sources by ABC News.


"This grand jury, in effect, came up with a compromise finding, 'No, it's not murder,' but, 'Yes, we think they were responsible' for the death based on abuse," ABC News legal analyst Dan Abrams said.


PHOTOS: JonBenet Ramsey: Never-Before-Seen Photos


But District Attorney Alex Hunter refused to sign off on the grand jury's decision, saying there was too little proof.


"I and my prosecution task force believe we do not have sufficient evidence to warrant the filing of charges against anyone who has been investigated at this time," Hunter said then.


Hunter believed a conviction would be impossible. Abrams said that he agrees with the decision.


"I've seen the majority of the case files and I think Alex Hunter made the right call," he said. "I think there simply was not enough evidence to move forward."


Patsy Ramsey died in 2006 after a battle with ovarian cancer. John Ramsey remarried. His attorney told ABC News that Hunter is "a hero who wisely avoided a miscarriage of justice."


The case is still officially open but, as in 1996, investigators seem no closer to solving the crime this year, when JonBenet would have turned 23.



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