False memories prime immune system for future attacks









































IN A police line-up, a falsely remembered face is a big problem. But for the body's police force – the immune system – false memories could be a crucial weapon.












When a new bacterium or virus invades the body, the immune system mounts an attack by sending in white blood cells called T-cells that are tailored to the molecular structure of that invader. Defeating the infection can take several weeks. However, once victorious, some T-cells stick around, turning into memory cells that remember the invader, reducing the time taken to kill it the next time it turns up.












Conventional thinking has it that memory cells for a particular microbe only form in response to an infection. "The dogma is that you need to be exposed," says Mark Davis of Stanford University in California, but now he and his colleagues have shown that this is not always the case.












The team took 26 samples from the Stanford Blood Center. All 26 people had been screened for diseases and had never been infected with HIV, herpes simplex virus or cytomegalovirus. Despite this, Davis's team found that all the samples contained T-cells tailored to these viruses, and an average of 50 per cent of these cells were memory cells.












The idea that T-cells don't need to be exposed to the pathogen "is paradigm shifting," says Philip Ashton-Rickardt of Imperial College London, who was not involved in the study. "Not only do they have capacity to remember, they seem to have seen a virus when they haven't."












So how are these false memories created? To a T-cell, each virus is "just a collection of peptides", says Davis. And so different microbes could have structures that are similar enough to confuse the T-cells.












To test this idea, the researchers vaccinated two people with an H1N1 strain of influenza and found that this also stimulated the T-cells to react to two bacteria with a similar peptide structure. Exposing the samples from the blood bank to peptide sequences from certain gut and soil bacteria and a species of ocean algae resulted in an immune response to HIV (Immunology, doi.org/kgg).












The finding could explain why vaccinating children against measles seems to improve mortality rates from other diseases. It also raises the possibility of creating a database of cross-reactive microbes to find new vaccination strategies. "We need to start exploring case by case," says Davis.












"You could find innocuous pathogens that are good at vaccinating against nasty ones," says Ashton-Rickardt. The idea of cross-reactivity is as old as immunology, he says. But he is excited about the potential for finding unexpected correlations. "Who could have predicted that HIV was related to an ocean algae?" he says. "No one's going to make that up!"












This article appeared in print under the headline "False memories prime our defences"




















































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Football: Beckham to make PSG bow against Marseille

 





PARIS: David Beckham will make his Paris Saint Germain debut in next weekend's Ligue 1 headline clash against Marseille, coach Carlo Ancelotti said on Saturday.

The 37-year-old Beckham, who signed a five-month contract with the French leaders last month, will skip Sunday's trip to Sochaux as he needs more time to get his fitness levels up to scratch, the Italian explained.

"No, he'll be staying here to work, he needs more training, he'll be ready next week for the game at home to Marseille... not necessarily to start, but to play" Ancelotti said.

"It's up to me to decide if he starts the match or not."

The former Manchester United and LA Galaxy star has a lot to give his new club, Ancelotti added.

"He can bring his experience, his quality, his professionalism, these are things that we need."

- AFP/fa




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Facebook pic of toy mortar leads to armed cops raid



The picture as it appears on Driscoll's Facebook page. Yes, that's a toy mortar.



(Credit:
Screenshot by Chris Matyszczyk/CNET)


When you make your Facebook profile picture that of Action Man (aka the British G.I. Joe), it can be a clue to your fascination with fantasy.


It also suggests that if there's a toy mortar in the background of the picture, that, too, might actually not be entirely real.


Please try telling that to the five carloads of police who raided Ian Driscoll's house in Tewkesbury, England, armed with guns and a search warrant.


"The Action Man looked a bit like me, so I decided to put it as my Facebook picture. I didn't even notice the mortar in the background," 43-year-old Driscoll explained to the Daily Mail.



The image offered more clues as to the mortar's unreality. There was a TV remote control by its side. It offered what some might call scale and perspective.


Sadly, perspective is not always something the police embrace with anything other than loaded arms.


"It's tiny and quite clearly a toy. I can't stop laughing. I think it's hilarious," Driscoll told the Mail.



More Technically Incorrect



The police did manage to see the funny side, but only after reportedly telling him that he was lucky he was at home, otherwise they would have been forced to break down his front door.


They didn't even seem to have considered that this profile picture had been up for a month.


It isn't clear which wise "friend" of Driscoll's contacted the police to tell them of his arms cache. It might have been polite of this person to at least own up to the marginal over-reaction.


A representative for the Gloucestershire police told the Mail: "We are sure that the community would rather we acted quickly on information given to us of this nature, in case it had turned out to be a weapon."


Many will be glad of the police's confidence in this matter. Perhaps a phone call to Driscoll might have obviated the necessity for a raid.


Still, it is heartening that he has stood his ground and continued to make believe that he is really Action Man.


The profile picture, with mortar in the background, is still on his Facebook page today.


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Picture Archive: Making Mount Rushmore, 1935-1941

Photograph from Rapid City Chamber of Commerce/National Geographic

There's no such thing as Presidents' Day.

According to United States federal government code, the holiday is named Washington's Birthday, and has been since it went nationwide in 1885.

But common practice is more inclusive. The holiday expanded to add in other U.S. presidents in the 1960s, and the moniker Presidents' Day became popular in the 1980s and stuck. It may be that George Washington (b. February 22, 1732) andAbraham Lincoln (b. February 12, 1809) still get the lion's share of attention—and appear in all the retail sale ads—on the third Monday in February, but the popular idea is that all 44 presidents get feted.

Mount Rushmore is a lot like that one day a year writ large—and in granite. It's carved 60 feet (18 meters) tall and 185 feet (56 meters) wide, from Washington's right ear to Lincoln's left.

The monument's sculptor, Gutzon Borglum, grew up in Idaho, a first-generation American born to Danish parents. He studied art in France and became good friends with Auguste Rodin. Borglum mostly worked in bronze, but in the early 1910s he was hired to carve the likenesses of Confederate leaders into Stone Mountain in Georgia.

He was about to be fired from that job for creative differences about the same time that a South Dakota historian named Doane Robinson had an idea. Robinson wanted to have a monument carved into the Black Hills of South Dakota, maybe Western historical figures like Chief Red Cloud and Lewis and Clark, each on their own granite spire. (Plan a road trip in the Black Hills.)

Robinson hired Borglum and gave him carte blanche. Borglum was looking for something with national appeal, so he chose to depict four presidents: George Washington, Thomas Jefferson, Theodore Roosevelt, and Abraham Lincoln.

Borglum wanted to represent the first 150 years of the nation's history, choosing four presidents as symbols of their respective time periods. He took a tour of western South Dakota, searching for an ideal canvas.

The sculptor was looking for three things: a surface strong enough to sculpt, a mountain big enough to hold several figures, and a mountain face that received morning sunlight. Mount Rushmore fit the bill and was already part of a national forest, so it was easy to set aside as a national memorial.

Work started in 1927. Calvin Coolidge attended the dedication ceremony. It took 14 years to finish the carving, conducted mostly in summertime because of the area's harsh winters.

There were approximately 30 workers on the mountain at any give time. In total about 400 had worked on it by the time the monument was finished. Though the project involved thousands of pounds of dynamite and perilous climbs, not a single person died during the work.

Borglum himself died of natural causes in 1941, though, just six months before the project was declared "closed as is" by Congress that Halloween. His son Lincoln—named for his father's favorite president—took over.

In the photo above, a worker refines the details of Washington's left nostril.

About 90 percent of the mountain was carved using dynamite, which could get within 3 to 5 inches (8 to 13 centimeters) of the final facial features. For those last few inches, workers used what was known as the honeycomb method: Jackhammer workers pounded a series of three-inch-deep holes followed up by chiselers who knocked off the honeycomb pieces to get the final shape. Then carvers smoothed the "skin's" surface.

—Johnna Rizzo

February 16, 2013

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Uncle: Pistorius Is 'Numb With Shock as Well as Grief'












Oscar Pistorius is "numb with shock as well as grief" his uncle told reporters Saturday as the Olympian amputee spent his second night behind bars in a South African jail for the allegedly killing his model girlfriend Reeva Steenkamp.


"All of us saw at firsthand how close [Steenkamp] had become to Oscar during that time and how happy they were," he said. "They had plans together and Oscar was happier in his private life than he had been for a long time," said Pistorius' uncle Arnold Pistorius.


The 26-year-old athlete, known as the "blade runner" because of the carbon-fiber blades he runs on, was charged Friday with premeditated murder.


Pistorius' family is "battling to come to terms with Oscar being charged with murder," Arnold Pistorius said, and still believe "there is no substance to the allegation."


Oscar Pistorius is suspected of shooting Steenkamp, 29, four times with a handgun early Thursday morning at his home in a gated community in Pretoria.


PHOTOS: Paralympic Champion Charged with Murder


Prosecutors dismissed the reports that Pistorious mistook her for an intruder.


If convicted, Pistorius could face at least 25 years in jail.


According to South African newspaper Beeld, Steenkamp was killed nearly two hours after police were called to Pistorius' home to respond to reports of an argument at the complex.


Police said they have responded to disputes at the sprinter's residence before, but did not say whether or not Steenkamp was involved.






Adrian Dennis/AFP/Getty Images; Mike Holmes/The Herald/Gallo Images/Getty Images











Oscar Pistorius Charged in Shooting Death of Girlfriend Watch Video









Oscar Pistorius: Inside Relationship With Slain Girlfriend Watch Video









Oscar Pistorius Murder Charges: Is He Capable of Killing? Watch Video





A memorial service for Steenkamp will be held in Port Elizabeth on Tuesday evening, reported SABC. Her body will be flown back for the service before being cremated, her family said.


"Her future has been cut short...I dare say she's with the angels," said Mike Steenkamp, Reeva Steenkamp's uncle.


Producers of the South African reality show Steenkamp competed in said the series will still premiere Saturday night on SABC as planned, but will now include a special tribute to the slain law school graduate whose modeling career was starting to take off.


RELATED: Reeva Steenkamp, Oscar Pistorius Girlfriend, Saw Self as 'Brainy, Blonde, Bombshell'


"This is the only time that you see the real Reeva," executive producer and director of "Tropka Island of Treasure" Samantha Moon told "Good Morning America." "She was kind and sweet and?so hard working.


"They will see the girl that we loved."


Meanwhile, the sprinter's sponsors ? including Nike, BT, Theirry Mugler, Oakley and Ossur, the Icelandic company that manufactures the prosthetic blades Pistorius races on ? are acting cautiously as the athlete awaits his bail hearing on Tuesday.


M-Net movies, a subscription-funded South African television channel has already pulled their ad campaign featuring Pistorius, tweeting, "Out of respect & sympathy to the bereaved, M-Net will be pulling its entire Oscar campaign featuring Oscar Pistorius with immediate effect."


Nike, who's ad featuring the double-amputee reads "I am the bullet in the chamber," released a statement saying the company is "continuing the monitor the situation closely."


Still, the athlete's' friends and colleagues said the murder charges have yet to sink in.


"When I heard, I was in shock and I'm just still trying to process it," Jamaican gold medal sprinter Usain Bolt told the Associated Press Friday night after the NBA All-Star celebrity game in Houston, Tex.


"I would just like to say, I have dated Oscar on and off for 5 YEARS, NOT ONCE has he EVER lifted a finger to me, made me fear for my life," his ex-girlfriend Jenna Edkins tweeted on Friday.


ABC News' Colleen Curry contributed to this report.



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Victory for gene patent firm in Australian court



































Your genes are the same, whether in a test tube or inside your body. But the very act of removing them makes them a patentable invention, according to Australia's Federal Court. Today, it handed down the country's first decision on gene patenting.












By isolating a human gene from the body, even assuming it has "precisely the same chemical composition and structure as that found in the cells of some human beings", Justice John Nicholas said an "artificial state of affairs" had been created, making the gene patentable material.












The ruling relates specifically to a patent for a series of mutations in the BRCA1 genes, which are associated with an increased risk of breast and ovarian cancer. Tests for the genes can help determine the likelihood of someone developing the diseases at a later date. The patent, which was filed by Myriad Genetics in 1994, in principle gives the company exclusive rights to perform such tests in Australia. The firm's patent was later contested by Cancer Voices Australia, a patient advocacy group, and Yvonne D'Arcy, who had previously had breast cancer.












Today's decision has raised eyebrows. "It is difficult to think of the circumstances where an artificially created state of affairs would not exist whenever there is some form of human intervention," says Dianne Nicol at the University of Tasmania, Australia, who specialises in law and human genetics.












She says the counter view is that isolating a gene from the body is similar to snapping a leaf from a tree: since the process is so commonplace, it doesn't represent a substantially artificial state of affairs.












It is likely the applicants will appeal, Rebecca Gilsenan, principal lawyer at Maurice Blackburn who represented Cancer Voices Australia, told New Scientist. "We and our client remain very committed in our opposition to gene patents," she says.











The ruling comes just two months before the US Supreme Court will hear an appeal over a very similar case between Myriad and the American Civil Liberties Union, which was awarded to Myriad in a lower court.













"Since patent criteria are similar, a decision in one jurisdiction can indicate what might happen in another," says Robert Cook-Deegan from the Duke Institute for Genome Sciences and Policy in Durham, North Carolina.












In Australia, Myriad licensed its BRCA1 patents to Genetic Technologies Limited. However, when Genetic Technologies threatened legal action to enforce its rights to the patents in 2008, a public outcry forced the company to allow other labs to freely perform BRCA1 testing.












"But there was – and still is – nothing in the law to prevent such an [enforcement] being made in the future," says Ian Olver, an oncologist and CEO of Cancer Council Australia, who is calling for the law to be changed to rule out gene patents.












In the US, where Myriad has enforced its patent, tests for BRCA1 must all be done by that company and can cost $3000.












For Australian genetic researchers, the patent's effect will be mitigated because in 2012 the country's judiciary introduced an "experimental use defence", whereby researchers investigating a patent's subject matter, or related areas, cannot be found to infringe the patent.


















































If you would like to reuse any content from New Scientist, either in print or online, please contact the syndication department first for permission. New Scientist does not own rights to photos, but there are a variety of licensing options available for use of articles and graphics we own the copyright to.




































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EU agrees to test for horse DNA in food labelling row






BRUSSELS: The European Union agreed on Friday the immediate launch of tests for horse DNA in meat products to reassure nervous consumers that their food is safe and to halt the horsemeat scandal spreading across Europe.

The test programme will also look for the presence of phenylbutazone, an anti-inflammatory treatment for horses which is harmful to humans and by law supposed to be kept out of the food chain.

The crisis continued meanwhile to build Friday as Austria and Norway confirmed that ready-to-eat "beef" meals containing horsemeat had been found, stoking concerns many more cases in more countries will come to light after falsely-labelled meat was found in Britain, France, Germany and Switzerland.

The scandal has left governments scrambling to figure out how and where the mislabelling happened in the sprawling chain of production spanning a maze of abattoirs and meat suppliers across Europe.

In Britain, the Food Standards Agency said that 29 out of 2,501 beef products it has tested so far have been found to contain more than one percent horsemeat but stressed that these must be considered exceptions.

"The overwhelming majority of beef products in this country do not contain horse. The examples we have had are totally unacceptable but they are the exceptions," FSA chief executive Catherine Brown said.

Brown added that the results were "still far from the full picture" and that testing continued.

French meat-processing firm Spanghero, blamed by Paris for the growing scandal, insisted again it was not responsible. "I don't know who is behind this but it is not us," Spanghero boss Barthelemy Aguerre told Europe 1 radio.

The French government on Thursday charged that Spanghero knowingly sold 750 tonnes of horsemeat mislabelled as beef over a period of six months, 500 tonnes of which were sent to French firm Comigel, which makes frozen meals at its Tavola subsidiary in Luxembourg.

That meat was used to make 4.5 million products that were sold by Comigel to 28 different companies in 13 European countries.

NorgesGruppen, Norway's largest retailer, said Friday that horsemeat was found in frozen lasagne dishes made by Comigel and sold in its stores and Austria said horsemeat was found in beef tortelloni sold in Lidl supermarkets.

Danish authorities said Friday they were probing whether a slaughterhouse may have mixed horsemeat into meat marked as beef that was supplied to pizza makers.

Under the measures agreed in Brussels, EU officials and statements said the testing of "foods destined for the final consumer and marketed as containing beef" could start immediately in member states, with the European Commission paying 75 percent of the costs for the first month.

The DNA controls, "mainly at the retail level", will include 2,250 samples across the EU, ranging from 10 to 150 tests per member state.

The phenylbutazone test will require one sample for every 50 tonnes of horsemeat, with each of the bloc's 27 states required to carry out a minimum of five tests.

EU Health Commissioner Tonio Borg, who proposed the plan at crisis talks on Wednesday, said he welcomed its swift approval and urged member states to keep up the momentum.

"I call on them to keep up the pressure in their efforts to identify a clear picture and a sequence of events," he said in a statement.

"Consumers expect the EU, national authorities and all those involved in the food chain to give them all the reassurance needed as regards what they have on their plates."

The test results will be reported to the European Commission by April 15 which will collate them in the EU's Rapid Alert System for Food and Feed (RASFF) so that they can be immediately used by member states.

- AFP/fa



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Why We Walk … and Run … And Walk Again to Get Where We're Going


You have to get to a bus stop to catch the once-an-hour express ... or to a restaurant to meet a friend ... or to a doctor's office. You've got maybe a half a mile to cover and you're worried you'll be late. You run, then you stop and walk, then run some more.

But wait. Wouldn't it be better to run the whole way?

Not necessarily.

A new study by an assistant professor of mechanical engineering at Ohio State University tests the theory that people subconsciously mix walking and running so they get where they need to. The idea is that "people move in a manner that minimizes energy consumption," said the professor, Manoj Srinivasan.

Srinivasan asked 36 subjects to cover 400 feet (122 meters), a bit more than the length of a football field. He gave them a time to arrive at the finish line and a stopwatch. If the deadline was supertight, they ran. If they had two minutes, they walked. And if the deadline was neither too short nor too far off, they toggled between walking and running.

The takeaway: Humans successfully make the walk-run adjustment as they go along, based on their sense of how far they have to go. "It's not like they decide beforehand," Srinivasan said. (Get tips, gear recommendations, and more in our Running Guide.)

The Best Technique for "the Twilight Zone"

"The mixture of walking and running is good when you have an intermediate amount of time," he explained. "I like to call it 'the Twilight Zone,' where you have neither infinite time nor do you have to be there now."

That ability to shift modes served ancient humans well. "It's basically an evolutionary argument," Srinivasan said. A prehistoric human seeking food would want to move in a way that conserves some energy so that if food is hard to find, the hunter won't run out of gas—and will still be able to rev it up to escape predators.

The study, published on January 30 in the Journal of the Royal Society Interface, doesn't answer that question of how we make such adjustments.

Runners: Take a Break if You Need It

The mix of walking and running is also something that nonelite marathoners are familiar with. Covering 26.2 miles might take less of a toll if the runner stops running from time to time, walks a bit, then resumes a jogging pace. "You use less energy overall and also give yourself a bit of a break," Srinivasan noted. (Watch: An elite marathoner on her passion for running.)

One take-home lesson is: Runners, don't push it all the time. A walk-run mix will minimize the energy you expend.

Lesson two: If you're a parent walking with your kid, and the kid lags behind, then runs to catch up, then lags again, the child isn't necessarily trying to annoy you. Rather, the child is perhaps exhibiting an innate ability to do the walk-run transition.

Potential lesson three: The knowledge that humans naturally move in a manner that minimizes energy consumption might be helpful in designing artificial limbs that feel more natural and will help the user reduce energy consumption.

The big question for Manoj Srinivasan: Now that he has his walk-run theory, does he consciously switch between running and walking when he's trying to get somewhere? "I must admit, no," he said. "When I want to get somewhere, I just let the body do its thing." But if he's in a rush, he'll make a mad dash.

"Talk to you tomorrow," he signed off in an email to National Geographic News. "Running to get to teaching now!"


Read More..

Cruise Ship Now Faces Expected Wave of Lawsuits












Despite having their feet back on solid ground and are making their way home, passengers from the Carnival Triumph cruise ship are still fuming over their five days of squalor on the stricken ship and the cruise ship company is likely to be hit with a wave of lawsuits.


"I think people are going to file suits and rightly so," maritime trial attorney John Hickey told ABCNews.com. "I think, frankly, that the conduct of Carnival has been outrageous from the get-go."


Hickey, a Miami-based attorney, said his firm has already received "quite a few" inquiries from passengers who just got off the ship early this morning.


"What you have here is a) negligence on the part of Carnival and b) you have them, the passengers, being exposed to the risk of actual physical injury," Hickey said.


Click Here for Photos of the Stranded Ship at Sea


The attorney said that whether passengers can recover monetary compensation will depend on maritime law and the 15-pages of legal "gobbledygook," as Hickey described it, that passengers signed before boarding, but "nobody really agrees to."


One of the ticket conditions is that class action lawsuits are not allowed, but Hickey said there is a possibility that could be voided when all the conditions of the situation are taken into account.


One of the passengers already thinking about legal action is Tammy Hilley, a mother of two, who was on a girl's getaway with her two friends when a fire in the ship's engine room disabled the vessel's propulsion system and knocked out most of its power.


"I think that's a direction that our families will talk about, consider and see what's right for us," Hilley told "Good Morning America" when asked if she would be seeking legal action.


While she said that she does not want to be greedy or exploit the situation, she does not feel that Carnival's $500 compensation is enough for the trauma passengers suffered.








Carnival's Triumph Passengers: 'We Were Homeless' Watch Video









Girl Disembarks Cruise Ship, Kisses the Ground Watch Video









Carnival Cruise Ship Passengers Line Up for Food Watch Video





"You talk about the emotional trauma and just last night, feeling what we went through last night while we were on land with our families and our insides just trembling," she said. "I don't think it begins to even say what is needed here."


In addition to the money, passengers will receive a full refund for the cruise, transportation expenses and vouchers for another cruise.


"We made our own nest [on deck] because we were just too terrified to go inside because of the smells and the germs, so we just banded together and made our own little nest and just survived," Hilley's friend Ann Barlow said.


Her friend Carolyn Klam said she got a stomach virus from drinking bad water once the power went out and friend Tammy Hilley said her cell phone was stolen this morning as the boat came into port.


"I think going back to our room was kind of traumatic and seeing that from day one we had no home, we were homeless," Hilley said. "We would go downstairs below deck and your feet could feel the sludge that you were walking through. The smells and the liquids draining from the ceiling and the stories of people sleeping in the hallways and the sanitary bags in the hallway, that was traumatic to just watch it start piling up."


The more than 4,000 passengers and crew began to disembark from the damaged ship around 10:15 p.m. CT Thursday in Mobile, Ala., amid cheers and tears. The last passenger left the ship at 1 a.m. CT, according to Carnival's Twitter handle.


Passenger Brandi Dorsett was thankful to be home, especially for her mother who was with her on the ship. Dorsett said she wasn't pleased with the doctor on staff.


"My mother is a diabetic, and they would not even come to the room because she cannot walk the stairs to help her with insulin. She hasn't had insulin in three days," Dorsett said.


The Carnival Triumph departed Galveston, Texas, last Thursday and lost power Sunday.


Cruise Ship Newlyweds Won't Be Spending Honeymoon on a Boat


After power went out, passengers texted ABC News that sewage was seeping down the walls from burst plumbing pipes, carpets were wet with urine, and food was in short supply. Reports surfaced of elderly passengers running out of critical heart medicine and others on board squabbling over scarce food.


"It's degrading. Demoralizing, and then they want to insult us by giving us $500," Veronica Arriaga said after disembarking the ship.


As the ship docked, passengers lined the decks of the Triumph, waving and whistling to those on shore. "Happy V-Day" read a homemade sign made for the Valentine's Day arrival, while another sent a starker message: "The ship's afloat, so is the sewage."


WATCH: Carnival CEO Gerry Cahill Apologizes to Passengers






Read More..

Sweat mutation may have helped us colonise Asia









































How did our species become the dominant one on Earth? Pinpointing the genetic changes that made this possible is one of the great challenges of evolutionary biology. Now, a team has developed a method that could allow us to reconstruct a detailed, step-by-step genetic history of our species spanning tens of thousands of years.












As a first step, they have identified a mutation that arose in east Asia and then was carried over to North America as our ancestors crossed the Bering Strait and colonised the New World.












"There is an archaeological record hidden in our DNA that can help point us to the traits that have been critical in human survival," says Pardis Sabeti of the Broad Institute in Cambridge, Massachusetts.











Sabeti's technique identifies versions of genes that have been created by random mutation and then retained - because they give their owners some natural advantage over individuals who do not have the mutation.













Gene variants that confer a survival advantage in this way can spread through a population – a process known as natural selection. But genes can also mutate and then spread by random chance even though they provide no specific advantage. In 2010, Sabeti developed a test that distinguishes the two possibilities.












The test works by looking for features that are associated with natural selection. For instance, when a gene spreads through natural selection, neighbouring stretches of DNA tend to also become more common, because they are attached to the favoured gene. So gene variants that have been selected for are often found surrounded by the same stretches of DNA, whereas those that have not been selected do not have consistent genetic neighbours.












Sabeti has now examined the genomes of 179 people from around the world, and used her test to pinpoint 412 DNA regions that have been strongly selected for.











The mutations in these regions represent key changes in human evolution over the last 40,000 years, after our ancestors first left Africa and were going global. The challenge now is to find out when each mutation arose, how it changed us, and why.












Hair and sweat













Sabeti's team made a start on this by examining the gene for the ectodysplasin A receptor (EDAR). Their analysis had revealed that one version of this gene, EDAR370A, is only found in some east Asians and Native Americans – among whom it is much more common than the original EDAR. Based on its modern distribution, Sabeti calculated that the mutation that gave rise to EDAR370A arose in China around 30,000 years ago.












To determine what changes the mutation brought about, she genetically modified mice to express EDAR370A.












This produced a catalogue of transformations. The modified mice had thicker hair fibres – as do Asians with EDAR370A. Their mammary glands also had smaller fat pads, which the team says may correlate with the fact that Asian women tend to have smaller breasts than African women.












Perhaps most importantly, the mutant mice had more sweat glands on the pads of their feet. When the team examined 623 Han Chinese people, they found that those with EDAR370A also had more sweat glands on their fingers.











Helpful mutation













It's not clear why EDAR370A was selected for. Any one of the changes it produces could have been beneficial, or perhaps it was a combination of the effects. "You can come up with a good story for all the traits," says team member Yana Kamberov of Harvard Medical School in Boston.











One possibility, the researchers say, is that the extra sweat glands helped humans to keep cool in the warm and humid Chinese climate of 30,000 years ago. That would fit with what we already know. Hunter-gatherers often bring down prey in long-distance chases, and being able to keep cool is essential for endurance running.













Alternatively, it could be all about sex. Men in Asia may have found small breasts more attractive, and thick hair may have been desirable generally. Such sexual selection can have a powerful effect on populations.












"I personally favour the idea that the traits could all have been acted on at different times," says Kamberov. She points out that the climate has changed dramatically since EDAR370A arose, so different effects of the gene may have been beneficial at different times. "It doesn't make sense to me that it was a one-hit wonder."












It's always tempting to make up just-so stories about human evolution, says Ewan Birney of the European Bioinformatics Institute in Cambridge, UK. "Sabeti didn't do that." He adds that using mice to figure out exactly what the mutated gene does is a key advance on previous studies.











Sabeti's work is the latest to identify genes that were important in the evolution of humans, and our subsequent history. In 2011, a study suggested that deletions of large chunks of DNA played a crucial role when the human family split from the ancestors of chimpanzees.












More recently, the SRGAP2 gene was found to have duplicated 2.5 million years ago. The extra copies may have allowed our brains to grow larger.












And within the last 70,000 years, interbreeding with Neanderthals gave us crucial immune genes that may have helped us go global.













Journal reference: 10.1016/j.cell.2013.01.035 and Cell, DOI: 10.1016/j.cell.2013.01.016


















































If you would like to reuse any content from New Scientist, either in print or online, please contact the syndication department first for permission. New Scientist does not own rights to photos, but there are a variety of licensing options available for use of articles and graphics we own the copyright to.




































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Mumbai attack movie hits cinemas on Mar 1






MUMBAI: Memories of the Mumbai terror attacks of November 2008 still evoke fear among residents of the city.

And those old wounds are expected to reopen now that a Bollywood movie about the incident is set to hit the big screens.

India's financial capital came to a virtual standstill on 26 November 2008.

The attacks which lasted for four days drew widespread global condemnation.

The Pakistan-based terrorists, who were members of Lashkar-e-Taiba, killed 164 people and wounded at least 308 in their wake.

But the undying spirit of the citizens of Mumbai helped the city crawl back to its feet soon after the carnage ended.

And now, Bollywood is all set to release a film which will depict the gruesome terror attacks that shook Mumbai nearly five years ago.

The movie "The Attacks of 26/11" will hit cinemas on 1 March.

A publicity event to launch the movie's music was held at the Gateway of India.

Around 200 students lit candles in memory of the 26/11 victims.

The event then continued at Café Leopold where two of the ten terrorists launched their initial strikes in the first wave of attacks on the city.

Film maker Ram Gopal Varma said: "I strongly believe as a film maker and as a human being that the attacks of 26/11 which happened in 2008 are not against any community in particular. I think it is an attack on human beings and committed by certain inhuman elements."

The mood was sombre as the film maker and lead actor showed off a few teasers from the movie.

The usually reclusive veteran Bollywood actor Nana Patekar, who plays the lead role in the film, shed his inhibitions and spoke to the media with unusual frankness.

He said: "I feel pained whenever I think about the attacks of 26/11. The film depicts the mindset of the terrorists who went on a carnage in Mumbai. We are trying to portray through our films what steps can be taken to prevent such types of attacks in future."

The owner of the Leopold was also present at the event, and has played himself in the film.

The music launch of the film has reignited the anger and bitterness in the minds of Indian citizens.

But as in 2008, the movie also shows the world that Mumbai and its people have picked up the pieces and are refusing to let fear of terror attacks get in the way of their daily lives.

- CNA/al



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Get rid of your ex on Valentine's, from Facebook at least



An ex is like a scar you once got after a seventh Cabernet in a bar with 12 steps.

Some days, you look at it and are proud. At other times, you wonder how you could have done it to yourself.


The lies, the hurt, the occasional odor of indifference and the underarm spray that was at least two years old -- they all serve as jogs and jags to the memory.


Sadly, many people still hold material relics of disappointed love all over the most important part of their lives -- yes, their Facebook timelines.


In the bowels of these definitive capsules lies the evidence of smiles that proved fake, hugs that proved self-serving, and the sharing of caramel cone ice cream that proved to be nothing more than a deceptive and fattening practice.


So to give your Valentine's Day a fresh start and a clean break, a mobile app called KillSwitch is launching, its sole purpose being to eradicate your ex from your Facebook timeline.


As Mashable reports, KillSwitch promises faithfully to hoover away at your past and suck up all the detritus of the one who once said she loved you more than she loved, well, herself. (C'mon. This is America. That couldn't possibly have been true.)


There's one important -- and potentially deal-breaking -- element to using this app. You and your ex must still be Facebook friends.


I know that for some the very first act after a breakup is to sever the Facebook friendship. (The second is severing ties on LinkedIn.)


Some, though, for reasons of laziness or hidden longing, keep that tenuous connection alive, just in case one party becomes less obstinate or less blind to what really happened.


KillSwitch puts an end to that maybe.



More Technically Incorrect



It digs deep and wide, in order to find any last image, wall post, status update, or poke. You then decide whether to delete them permanently or keep them in a secret KillSwitch folder for a snowy day (in Hell).


Though it costs a whole 99 cents, some of the money will go to the American Heart Association of New York. (It's available as an
Android app in the Google Play store and "coming soon" to the Apple App Store.)


With some exes, it can take awhile to remove all trace -- 4,000 posts took 15 minutes, according to the people behind the app. (4,000 posts? Who does that?)


But if your relationship was a mere superficial shell, then you can be done with all the evidence before you've had 10 slurps of your cappuccino.


Naturally, one could suggest that you could avoid the need for such technology, if you didn't feel such a desperate need to plaster the Web with pictures of every stage of every relationship.


But life these days is about display before dismay, isn't it?


Read More..

Are Honeybees Losing Their Way?



A single honeybee visits hundreds, sometimes thousands, of flowers a day in search of nectar and pollen. Then it must find its way back to the hive, navigating distances up to five miles (eight kilometers), and perform a "waggle dance" to tell the other bees where the flowers are.


A new study shows that long-term exposure to a combination of certain pesticides might impair the bee's ability to carry out its pollen mission.


"Any impairment in their ability to do this could have a strong effect on their survival," said Geraldine Wright, a neuroscientist at Newcastle University in England and co-author of a new study posted online February 7, 2013, in the Journal of Experimental Biology.


Wright's study adds to the growing body of research that shows that the honeybee's ability to thrive is being threatened. Scientists are still researching how pesticides may be contributing to colony collapse disorder (CCD), a rapid die-off seen in millions of honeybees throughout the world since 2006.


"Pesticides are very likely to be involved in CCD and also in the loss of other types of pollinators," Wright said. (See the diversity of pollinating creatures in a photo gallery from National Geographic magazine.)


Bees depend on what's called "scent memory" to find flowers teeming with nectar and pollen. Their ability to rapidly learn, remember, and communicate with each other has made them highly efficient foragers, using the waggle dance to educate others about the site of the food source.



Watch as National Geographic explains the waggle dance.


Their pollination of plants is responsible for the existence of nearly a third of the food we eat and has a similar impact on wildlife food supplies.


Previous studies have shown certain types of pesticides affect a bee's learning and memory. Wright's team wanted to investigate if the combination of different pesticides had an even greater effect on the learning and memory of honeybees.


"Honeybees learn to associate floral colors and scents with the quality of food rewards," Wright explained. "The pesticides affect the neurons involved in these behaviors. These [affected] bees are likely to have difficulty communicating with other members of the colony."


The experiment used a classic procedure with a daunting name: olfactory conditioning of the proboscis extension reflex. In layman's terms, the bee sticks out its tongue in response to odor and food rewards.


For the experiment, bees were collected from the colony entrance, placed in glass vials, and then transferred into plastic sandwich boxes. For three days the bees were fed a sucrose solution laced with sublethal doses of pesticides. The team measured short-term and long-term memory at 10-minute and 24-hour intervals respectively. (Watch of a video of a similar type of bee experiment.)


This study shows that when pesticides are combined, the impact on bees is far worse than exposure to just one pesticide. "This is particularly important because one of the pesticides we used, coumaphos, is a 'medicine' used to treat Varroa mites [pests that have been implicated in CCD] in honeybee colonies throughout the world," Wright said.


The pesticide, in addition to killing the mites, might also be making honeybees more vulnerable to poisoning and effects from other pesticides.


Stephen Buchmann of the Pollinator Partnership, who was not part of Wright's study, underscored how critical pollinators are for the world. "The main threat to pollinators is habitat destruction and alteration. We're rapidly losing pollinator habitats, natural areas, and food-producing agricultural lands that are essential for our survival and well being. Along with habitat destruction, insecticides weaken pollinators and other beneficial insects."


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Tempers and Compensation on Cruise Ship Rising













The 4,000 passengers and crew aboard the stricken Carnival Triumph cruise ship will disembark after dark tonight from the fetid cruiser dubbed "the poop deck" on social media, according to officials.


"It will come in. It will not stop," Alabama State Port Authority Director Jimmy Lyons said at a news conference today. "We're going to do everything we can from our standpoint to ensure that this is as smooth as possible."


He estimated the ship would arrive between 7 p.m. and 10 p.m. tonight.


Delighted passengers waved at media helicopters that flew out to film the ship and passenger Rob Mowlam told ABCNews.com by phone today that most of the passengers on board were "really upbeat and positive."


Nevertheless, when he gets off Mowlam said, "I will probably flush the toilet 10 times just because I can."


Mowlam, 37, got married on board the Triumph Saturday and said he and his wife, Stephanie Stevenson, 27, haven't yet thought of redoing the honeymoon other than to say, "It won't be a cruise."


Lyons said that with powerless "dead ships" like the Triumph, it is usually safer to bring them in during daylight hours, but, "Once they make the initial effort to come into the channel, there's no turning back."


Click here for photos of the stranded ship at sea.






Lt. Cmdr. Paul McConnell/U.S. Coast Guard/AP Photo











Carnival Cancels All Scheduled Voyages Aboard the Triumph Watch Video









Carnival Cruise Ship Making Its Way to Port Watch Video









Carnival Cruise Ship Stranded for Third Day Watch Video





"There are issues regarding coming into the ship channel and docking at night because the ship has no power and there's safety issues there," Richard Tillman of the Mobile Bay Convention and Visitors Bureau told ABCNews.com.


When asked if the ship could be disembarked in the dark of night, Tillman said, "It is not advised. It would be very unusual."


Carnival Cruise Senior Vice President of Marketing Terri Thornton, however, insisted during a news conference at the port of Mobile today, "Our understanding is it will be alongside this evening."


Thornton denied the rumors that there was a fatality on the ship. He said that there was one illness early on, a dialysis patient, but that passenger was removed from the vessel and transferred to a medical facility.


The U.S. Coast Guard is assisting now and there are multiple generators on board. And customs officials will board the ship while it is being piloted to port to accelerate the embarkation, officials said.


After eight miserable days at sea, the ship's owners have increased the compensation for what some on board are calling the vacation from hell.


All 3,143 passengers aboard the 900 foot colossus, which stalled in the Gulf of Mexico after an engine room fire early Sunday, were already being given a full refund for the cruise, transportation expenses and vouchers for a another cruise. Carnival Cruise Lines is now boosting that offer to include another $500 per person. Gerry Cahill, president and CEO of Carnival Cruise Lines, announced the additional compensation Wednesday.


"We know it has been a longer journey back than we anticipated at the beginning of the week under very challenging circumstances," he said in a statement. "We are very sorry for what our guests have had to endure. Therefore, in addition to the full refund and future cruise credit already offered, we have decided to provide this additional compensation."


Carnival also said that it has canceled a dozen planned voyages for the Triumph and acknowledged that the crippled ship had been plagued by other mechanical problems in the weeks before an engine-room fire left it powerless in the Gulf of Mexico.






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Asteroid to give Earth a record close shave on Friday



































Earth is about to dodge a bullet. An asteroid will buzz the planet on 15 February, coming closer than many communications satellites.












At 45 metres wide, the space rock is the biggest object in recorded history to swoop this close to Earth. Were it to collide with the planet, it would cause devastation akin to the 1908 Tunguska event that flattened 2000 square kilometres of trees in Siberia.











Astronomers have been tracking the object, called 2012 DA14, since it was discovered a year ago. It will pass about 27,500 kilometres above Earth's surface, making its closest approach over Indonesia at 7.24 pm GMT. In dark, clear skies the asteroid will be visible with binoculars.












Closer look












There is no risk of a collision, but the near miss offers a chance to observe the asteroid up close, for instance, using radar to map its surface. This was done in late 2011 with the asteroid 2005 YU55, which didn't come as near to Earth but was a whopping 400 metres across. Astronomers got a detailed view of a surface covered with craters.













"2012 DA14 is a much smaller object, so won't look this good," says Amy Mainzer of NASA's Jet Propulsion Lab in Pasadena, California. Still, the radar images should give a better sense of the object's shape and spin, which will improve our understanding of its likely future path, she says.












"Right now astronomers expect that Earth's gravity will shift the asteroid's orbit closer to the sun, which means it is unlikely to get cosy with our planet again for another 100 years.











Astronomers also hope to read the object's spectrum - chemical clues in its reflected light that can reveal its composition, says JPL's Donald Yeomans. This can help studies of all near-Earth asteroids, he says: "If you can match up spectral types of asteroids to a corresponding meteorite type, which has been studied to death on the ground, then you know what this thing is made of at the elementary level."



















































If you would like to reuse any content from New Scientist, either in print or online, please contact the syndication department first for permission. New Scientist does not own rights to photos, but there are a variety of licensing options available for use of articles and graphics we own the copyright to.




































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Olympics: Wrestlers vow to fight Olympic removal






PARIS: Wrestlers around the world on Wednesday vowed to fight to save the ancient sport's Olympic status, after the International Olympic Committee voted to drop it for the 2020 Games.

Japan and Turkey -- whose cities Tokyo and Istanbul are bidding to host the Games in seven years' time -- led the calls for the world body to reconsider, as an online petition was organised urging a rethink and gained thousands of supporters.

The president of the Turkish wrestling federation, Hamza Yerlikaya, called the decision, taken at the IOC executive board meeting in Lausanne, Switzerland, on Tuesday, "unfair" and a "mistake" that they would seek to overturn.

"To have the 2020 Olympics in Istanbul without wrestling is unthinkable," said Yerlikaya, himself a double Olympic gold medallist, three-time world champion and eight-time European champion in Greco-Roman wrestling.

"We won't allow it," he added.

In Japan, Yerlikaya's counterpart Tomiaki Fukuda said on his federation's website that he was "dissatisfied and baffled", echoing the views of the sport's world governing body, which called the decision "an aberration".

Wrestling will remain on the programme for the 2016 Olympics in Rio de Janeiro but faces a fight against seven other sports for inclusion at the Games four years later. A final decision is to be made when all IOC members meet in September.

Members are seen as unlikely to vote against the executive board, however, raising the prospect that one of the few sports that survived from the original Olympics in ancient Greece into the modern era will disappear.

Wrestling first appeared in 708 BC and has only ever been left out of the Olympic programme once before in 1900.

The International Federation of Associated Wrestling Styles (FILA) has vowed to fight the decision, while multiple medallists Russia and Iran have also said they hoped the IOC would backtrack.

"This issue will definitely be a big blow to the country's sport, as it is one of our country's most popular sports," the head of Iran's national Olympic commitee, Mohammad Aliabadi was quoted as saying in Iranian media, "I will certainly pursue the case."

IOC president Jacques Rogge meanwhile insisted on Wednesday that the vote -- by secret ballot -- was fair and said he understood the angry response from those involved in the sport.

A meeting was planned between the committee and the International Federation of Associated Wrestling Styles (FILA), to discuss the matter, he told a news conference in Lausanne.

Wrestlers have been left dismayed by the decision, with Japan's undisputed queen of the ring, Saori Yoshida, saying: "I am so devastated that I don't know what to do."

Yoshida, a 55kg-class freestyle wrestler who is the face of Tokyo's campaign for the right to host the 2020 Games, has won a record 13 straight Olympic and world championship gold medals over 10 years.

In India, Sushil Kumar, who won a bronze in Beijing and a silver in London last year, said: "I still can't get over the news that we won't be at the Olympics.

"All sportsmen look towards the Olympics as the pinnacle of excellence, everyone wants to take part in them. Now what do we do? Give up wrestling? I hope the IOC will reconsider this decision."

An online petition at change.org entitled "The International Olympic Committee: Save Wrestling as an Olympic sport #SaveOlympicWrestling" has also been mounted, urging the US Senate to take up the matter.

By late afternoon on Wednesday, it had more than 21,000 signatures.

On Twitter, one user, @WrestlersLoveUs, wrote: "Ancient Olympic wrestlers used to sometimes fight to the death. IOC better understand we're ready to do that again. #SaveOlympicWrestling."

-AFP/fl



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Skype 6.2 arrives for Windows, Mac



Microsoft's Skype team today rolled out two new updates, both labeled as version 6.2, for Windows and Mac.


The Windows version includes a redesigned top toolbar that brings together main actions, like calling phones, creating groups, and adding contacts. It also includes "eGifting," or the ability to send Skype credits to users on their birthday which the recipients can use anytime.


Another feature in the Skype 6.2 for Windows release includes the option to send an instant message using ctrl+enter. This version drops support for PCs using Intel Pentium 3 or similar CPUs which don't support SSE2 instructions.


The Skype for Mac 6.2 update includes the same eGifting capability. It also adds support for one-way SMS without the addition and verification of the user's mobile number.


The
Mac update includes several bug fixes, including problems with signing out of Facebook, and issues around the display of Messenger contacts in a Skype contact group.

This story originally appeared at ZDNet under the headline "Skype rolls out 6.2 updates for Windows, Mac."


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Obama Pledges U.S. Action on Climate, With or Without Congress


If there were anything in President Barack Obama's State of the Union to give hope to wistful environmentalists, it was the unprecedented promise to confront climate change with or without Congress, and to pursue new energy technology in the process.

Following his strong statements in his inaugural address about the ripeness of the moment to address a changing climate, Obama outlined a series of proposals to do it. Recognizing that the 12 hottest years on record all occurred in the last decade and a half, Obama said his most ambitious goal would be a "bipartisan, market-based solution," similar to the cap-and-trade system that died in Congress during his first term.(See related story: "California Tackles Climate Change, But Will Others Follow?")

But without legislative action, Obama threatened to act himself using executive authority. "I will direct my Cabinet to come up with executive actions we can take, now and in the future, to reduce pollution, prepare our communities for the consequences of climate change, and speed the transition to more sustainable sources of energy," he said. That will translate, White House officials said earlier in the week, to new regulations for existing coal-burning power plants and directives to promote energy efficiency and new technology research. (See related story: "How Bold a Path on Climate Change in Obama's State of the Union?")

The effort isn't one that can be stalled, he noted. Not just because of a warming planet, but also because of international competition from countries like China and parts of Western Europe that have gone "all in" on clean energy.

Energy experts signaled support of Obama's comments on energy security, including a plan for an Energy Security Trust to use revenue from oil and gas production on public lands to fund new energy research. "Clean energy businesses commend the president for reaffirming his commitment to reduce greenhouse gas emissions and to address the damaging and costly impacts of climate change," Lisa Jacobson, president of Business Council for Sustainable Energy, said in a statement. The influential League of Conservation Voters perked up to Obama's vow to act on climate change, even if alone.

Noticeably unmentioned in the speech was the Keystone XL pipeline that would carry oil from Canadian tar sands to the refining centers of Texas. Environmentalists have urged Obama to reject the project's application for federal approval in order to hold the line against carbon-intensive production from the oil sands. (See related blog post: "Obama and Keystone XL: The Moment of Truth?") Energy analysts believe Obama is likely to approve the project in the coming weeks, yet at the same time offer new regulations on domestic oil and natural gas development.

Other environmental analysts took Obama's remarks as simple talk, so far not backed by action. “How many times do we have to have the problem described?” David Yarnold, president of the Audubon Society said after the speech. “Smarter standards for coal-fired power plants are the quickest path to a cleaner future, and the president can make that happen right now.”

Obama's path toward accomplishing those goals will likely be lonely. In the Republican rebuttal to Obama's speech, Florida Senator Marco Rubio sidelined climate change as an issue of concern and highlighted the deep partisan distrust. "When we point out that no matter how many job-killing laws we pass, our government can’t control the weather, he accuses us of wanting dirty water and dirty air," Rubio said. He echoed the long-held Republican concern that remaking an economy may not be the wisest way to confront the problem of extreme weather.

Central to Obama's efforts will be his nominees to lead the Environmental Protection Agency and the Department of Energy in his second term. Both roles were at times attacked over his first term, notably when EPA instituted new air and water regulations and DOE was caught making a bad investment in the now-defunct solar manufacturer Solyndra. If the tone of his State of the Union offers a blueprint, he'll choose people unafraid to act.

This story is part of a special series that explores energy issues. For more, visit The Great Energy Challenge.


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Charred Human Remains Found in Burned Cabin













Investigators have located charred human remains in the burned-out cabin where they believe suspected cop killer and ex-LAPD officer Christopher Dorner was holed up as the structure burned to the ground, police said.


The human remains were found within the debris of the burned cabin and identification will be attempted through forensic means, the San Bernardino County Sheriff-Coroner Department said in a news release early this morning.


Dorner barricaded himself in the cabin in the San Bernardino Mountains near Big Bear Tuesday afternoon after engaging in a gunfight with police, killing one officer and injuring another, the San Bernardino County Sheriff's Department said.


Cindy Bachman, a spokeswoman for the department, which is the lead agency in the action, said Tuesday night investigators would remain at the site all night.


FULL COVERAGE: Christopher Dorner Manhunt


When Bachman was asked whether police thought Dorner was in the burning cabin, she said, "Right. We believe that the person that barricaded himself inside the cabin engaged in gunfire with our deputies and other law enforcement officers is still inside there, even though the building burned."


Bachman spoke shortly after the Los Angeles Police Department denied earlier reports that a body was found in the cabin, contradicting what law enforcement sources told ABC News and other news organizations.


Police around the cabin told ABC News they saw Dorner enter but never leave the building as it was consumed by flames, creating a billowing column of black smoke seen for miles.


A news conference is scheduled for later today in San Bernardino.


One sheriff's deputy was killed in a shootout with Dorner earlier Tuesday afternoon, believed to be his fourth victim after killing a Riverside police officer and two other people this month, including the daughter of a former police captain, and promising to kill many more in an online manifesto.



PHOTOS: Former LAPD Officer Suspected in Shootings








Carjacking Victim Says Christopher Dorner Was Dressed for Damage Watch Video









Christopher Dorner Manhunt: Inside the Shootout Watch Video









Chris Dorner Manhunt: Fugitive Ex-Cop in Shootout With Police Watch Video





Cops said they heard a single gunshot go off from inside the cabin just as they began to see smoke and fire. Later they heard the sound of more gunshots, which was the sound of ammunition being ignited by the heat of the blaze, law enforcement officials said.


Police did not enter the building, but shot tear gas inside.


One of the largest dragnets in recent history, which led police to follow clues across the West and into Mexico, apparently ended just miles from where Dorner's trail went cold last week.


It all began at 12:20 p.m. PT Tuesday, when a maid working at a local resort called 911, saying she and another worker had been tied up and held hostage by Dorner in a cabin, sources said.


The maid told police she was able to escape, but Dorner had stolen one of their cars, which was identified as a purple Nissan.


The San Bernardino Sheriff's Office and state Fish and Wildlife wardens spotted the stolen vehicle and engaged in a shootout with Dorner.


Officials say Dorner crashed the stolen vehicle and fled on foot only to commandeer Rick Heltebrake's white pickup truck on a nearby road a short time later.


"[Dorner] said, 'I don't want to hurt you, just get out and start walking up the road and take your dog with you.' He was calm. I was calm. I would say I was in fear for my life, there was no panic, he told me what to do and I did it," Heltebrake said.


"He was dressed in all camouflage, had a big assault sniper-type rifle. He had a vest on like a ballistic vest," Heltebrake added.


The white pickup truck bought Dorner extra time because police were still looking for the purple Nissan, California Department of Fish and Wildlife Lt. Patrick Foy told "Good Morning America" today.


"We were looking for a purple color Nissan and all of a sudden this white pickup starts coming by in the opposite direction. That's not the suspect's vehicle that we had been looking for," Foy said.


A warden with the Fish and Wildlife department noticed Dorner driving and the pursuit picked up again, Foy said.


"Ultimately, the officer who was driving that vehicle stopped and pulled out his patrol rifle and engaged probably 15 to 20 shots as Dorner was driving away," Foy said.


Dorner then ran on foot to the cabin in which he barricaded himself and got in a shootout with San Bernardino County sheriff's deputies and other officers who arrived.


The two deputies were wounded in the firefight and airlifted to a nearby hospital, where one died, police said. The second deputy was in surgery and was expected to survive, police said.


Police sealed all the roads into the area, preventing cars from entering the area and searching all of those on the way out. All schools were briefly placed on lockdown.


Believing that Dorner might have been watching reports of the standoff, authorities asked media not to broadcast images of police officers' surrounding the cabin, but sent him a message.


"If he's watching this, the message is: Enough is enough," Los Angeles Police Department spokesman Andy Smith told reporters at a news conference Tuesday. "It's time to turn yourself in. It's time to stop the bloodshed. It's time to let this event and let this incident be over."






Read More..

Today on New Scientist: 12 February 2013







Exploring oscillation proves a moving experience

From the animating pigs' hearts to diving into an acoustic pod, an exhibition exploring the world of oscillation is full of surprises



Gene therapy cures diabetic dogs

Diabetic beagles haven't needed an insulin injection for four years following treatment with two genes that work together to regulate glucose



Withering heights: Why animals are shrinking

It might sound incredible, but many animals are shrinking - and they will become ever tinier in the centuries to come



Suspicious quake gives away North Korea's third nuke

The magnitude-4.9 earthquake was probably due to a 10-kiloton underground nuclear bomb; the next step is to monitor for signs of radioactive gas



Latest Landsat in 40-year mission blasts off

The Landsat Data Continuity Mission, the newest addition to NASA's 40-year mission monitoring Earth from space, blasted into orbit yesterday



Robotic tormenter depresses lab rats

A new robotic rat induces stress and depression in lab animals, creating models of psychological disorders for testing new drugs



Curiosity's first drilling hints at Martian mining

The NASA rover has sampled beneath the Martian surface, perhaps laying the groundwork for future craft to build on or even mine the Red Planet



Algorithm learns how to revive lost languages

An automated system that reconstructs ancient languages could help recover the sound of words not spoken for thousands of years



Arctic sunshine cranks up threat from greenhouse gases

Soil microbes break down organic matter in permafrost more rapidly when exposed to ultraviolet light, so sunshine could speed up carbon dioxide release



Trading places with us makes robots better teammates

It's good when co-workers understand each other - especially if one of them is a robot. Read how a mechanical arm learned the mind of Celeste Biever



Wind power is now cheaper than coal in some countries

Steady technological improvements and uncertainty over the future of fossil fuels are making wind power truly competitive




Read More..

Horsemeat disguised as beef confirmed in France: company






PARIS: A major French frozen food retailer said on Tuesday it had found horsemeat in two lots of frozen beef lasagne meals it removed from its shelves last week.

Picard, which has hundreds of outlets across France that sell ready-to-eat meals, said the products were made by Comigel, the French firm which last week sparked the frozen food scandal now spreading across Europe.

- AFP



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iTunes now Apple's fourth-largest business, says analyst



Apple's iTunes generated revenue of $13.5 billion last year, making it the company's fourth-largest business, according to Asymco analyst Horace Dediu.


A business that simply broke even a few years ago has been rising "steadily and rapidly," Dediu said in a post yesterday.
iTunes has averaged growth of more than 30 percent over the past two years. The $13.5 billion in sales in 2012 was up from $10.2 billion in 2011.


At the same time that iTunes is adding a greater chunk of sales to Apple's overall results, the
Mac and
iPod lineups are contributing less. If this trend continues, iTunes could become Apple's third-largest business sometime this year, forecasts Dediu.

Another business already bigger than the Mac is Apple's Accessories line, which includes products such as Apple TV. As Dediu points out, iTunes and Apple accessories depend on hardware sales to thrive. But the results show that these "ancillary" businesses are contributing more than their fair share.

"Indeed, if seen in isolation, iTunes plus Accessories combined is a bigger business in terms of revenues than any of the other phone vendors except Samsung," Dediu said.

Read More..

What Killed Dinosaurs: New Ideas About the Wipeout


New insights about the asteroid thought to have killed off the dinosaurs suggest it may have just been the final blow, and that the reptiles were already suffering from a finicky climate prompted by volcanic eruptions long before the meteorite struck.

"The [asteroid] impact was the coup de grace," Paul Renne, a geologist at the University of California, Berkeley, said in a statement.

The research, detailed in the February 8 issue of the journal Science, adds to the ongoing scientific debate over what exactly killed off the dinosaurs.

That debate, which once revolved around the question of whether the culprit was an asteroid or volcano-induced climate changes, has evolved to consider the possibility that perhaps multiple environmental factors were involved.

Renne and his team recently determined the most precise date yet for the asteroid strike, which occurred in the Yucatan peninsula in what is now Mexico.

Using a high-precision dating technique on tektites—pebble-sized rocks formed during meteorite impacts—from Haiti that were created during the event, the team concluded that the impact occurred 66,038,000 years ago—slightly later than previously thought.

When error limits are taken into account, the new date is the same as the date of the extinction, the team says, making the events simultaneous.

Renne said the new findings, should lay to rest any remaining doubts about whether an asteroid was a factor in the dinosaurs' demise.

"We have shown that these events are synchronous to within a gnat's eyebrow," he said, "and therefore the impact clearly played a major role in extinctions."

That is not to say, however, that the asteroid—which carved out the so-called Chicxulub crater—was the sole cause of the dinosaurs' extinction.

Evidence now suggests massive volcanic eruptions in India that predated the asteroid strike also played a part, triggering climate changes that were already killing off some dinosaur groups.

For example, "nobody has ever found a non-avian dinosaur fossil exactly at the impact layer," Renne said in an email. "Hence, strictly speaking, the non-avian dinosaurs"—those dinosaurs unrelated to birds—"may have already gone extinct by the time of the impact."

Death From the Skies

The idea that volcanism was responsible for the dinosaurs' demise actually predates the impact theory, and it fits well with what is known about Earth's other mass extinction events.

"Many of the other mass extinctions have been found to co-occur with large-scale volcanic eruptions," said Heiko Pälike, a paleoceanographer at the University of Bremen in Germany.

But in the 1980s, father-son team Luis and Walter Alvarez, a physicist and planetary scientists, respectively, presented a bold new theory.

After discovering that a layer of clay that's found throughout the world and that coincided with the end of the Cretaceous period is enriched in iridium—an element rare on Earth but common in space rocks—they proposed that a meteorite wiped out the dinosaurs.

"As the impact theory took hold, especially with the more physical scientists ... the volcanists lost ground," Renne explained.

The impact theory gained further momentum in the 1990's, when scientists discovered a 110-mile (180-kilometer) wide impact crater in the Yucatan peninsula that dated to the boundary between the Cretaceous and Tertiary periods—the so-called KT boundary—when the dinosaurs disappeared.

The crater's size indicated that whatever created it was roughly 6 miles (10 kilometers) in diameter.

An asteroid of that size striking the Earth would have had devastating consequences, including destructive pressure waves, global wildfires, tsunamis, and a "rain" of molten rock reentering the atmosphere.

Additionally, "much additional particulate matter would have stayed afloat in the atmosphere for weeks, months, perhaps years, blocking incoming solar radiation and thus killing plant life and causing catastrophic drops in temperatures," explained Hans-Dieter Sues, a paleontologist at the Smithsonian National Museum of Natural History in Washington, D.C.

Hybrid Theory for Dinosaur Extinction

The once-abandoned volcanism theory has seen a revival of sorts in recent years, however, as a result of fresh insights about a period of sustained ancient volcanic activity in India and the discovery that dinosaur diversity may have already been declining before the asteroid strike.

The debate now is "whether the Chicxulub impact was the 'smoking gun,' as many researchers claim," Sues said, "or one of several causative factors, kind of like 'Murder on the Orient Express.'"

Renne belongs to the camp that thinks a series of volcanic eruptions in India that produced ancient lava flows known as the Deccan Traps caused dramatic climate variations, including long cold snaps, that may have already been culling the dinosaurs before the asteroid struck.

"It seems clear that volcanism alone, if on a sufficiently massive and rapid scale, can trigger extinctions," Renne said. "Thus my view that the impact was probably the final straw, but not the sole cause."

Unanswered questions

The new hybrid theory still has some major questions it must answer, however, like precisely how much the Indian volcanic eruptions affected the dinosaurs.

"Some people say if you look at the eruption of Mount Pinatubo [in 1991], it cooled the Earth for a short period of time due to the aerosol and the dust that was ejected," Pälike said.

But "others say in the long run volcanoes probably pump more carbon dioxide into the atmosphere and actually warm the planet, at least temporarily."

It's also unclear how the Deccan Traps eruptions were spread out in time. "We know that they started a few million years before the end of the Cretaceous and lasted for several million years after, extending even beyond the [asteroid impact]," Pälike said.

"However, some people have suggested that there were clusters of eruptions that happened within a span of a few tens of thousands of years."

Knowing the timing of the eruptions is important, Pälike added, because if they were happening close to the end of the Cretaceous, it's more likely they played a role in the dinosaurs' extinction than if most of the eruptions happened two million years before.

Pälike thinks that more precise dating of the volcanic ash layers in India could help answer some of the remaining questions: "That's the next step of the puzzle."

Pinning down the cause of the dinosaurs' extinction isn't just of academic interest, said Jonathan Bloch, associate curator of vertebrate paleontology at the Florida Museum of Natural History at the University of Florida.

"It's important for us to understand how ecosystems respond to big perturbations," Bloch said, "whether it's gradual climate change or a catastrophic event. These are all things we have to think about as humans on the planet today."


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